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KMID : 1191520200250020037
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Journal of Korean Traditional Oncology
2020 Volume.25 No. 2 p.37 ~ p.49
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A Literature Review of Management for Opioid-Induced Constipation in Cancer Patients
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Yoon Jee-Hyun
Kim Eun-Hye
Lee Jee-Young
Yoon Seong-Woo
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Abstract
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Objective: Constipation is the most common adverse effect of opioid analgesic therapy in cancer patients. This can be associated with physical and emotional distress to cancer patients. The purpose of this study is to review the standard and alternative interventions of the management for opioid-induced constipation (OIC).
Methods: The studies were searched from databases, including Pubmed, Google scholar, KISS, NDSL, and OASIS. The main search terms included such as constipation, opioid, opioid-induced constipation, cancer, management, herb, and acupuncture.
Results: The prevention and usual care of constipation is a key tool for the management of OIC. Also, prophylactic laxatives starting concurrently with opiates helped to prevent developing constipation. Peripherally acting μ-opioid receptor antagonists (PAMORAs) significantly reduced OIC and well-tolerated. In addition, acupuncture, herb medicines, and interferential current or transcutaneous electrical nerve stimulation to acupoints had effectiveness in reducing constipation.
Conclusion: Preliminary data indicate that PAMORAs and Traditional Korean Medicine may be considered as the management of unresolved OIC. However, due to the limited articles, more systematic and rigorous clinical trials are needed.
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KEYWORD
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Opioid-induced constipation, Literature review, Opioid, Cancer, Traditional Korean Medicine
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